研究室紹介

生薬学分野

スタッフ

科目ごとのオフィスアワーはシラバスを確認してください

スタッフ 主な担当科目 オフィスアワー
准教授 久保山 友晴 (博士 (薬学))
(研究室主任)
本草学
漢方・民間薬概論
水曜日 15:00~17:00
不在の場合はメールにて対応

助手 大渡 勝史(農学修士)
(薬用植物園)

化学系実習

火曜日 13:00~17:00
不在の場合はメールにて対応

研究内容
  • 難治性神経疾患(アルツハイマー病、脊髄損傷、不安障害など)における神経回路網破綻の機序の解明とこれを克服する手法の開発
  • 和漢薬をはじめとする世界各国の伝統医学で用いられる生薬及びその成分の包括的な薬理作用の解析
代表論文

久保山

  • Tohda C, Matsui M, Inada Y, Yang X, Kuboyama T, Kimbara Y, Watari H. Combined Treatment with Two Water Extracts of Eleutherococcus senticosus Leaf and Rhizome of Drynaria fortunei Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults. Nutrients 2020, 12, 303.
  • Tanabe N, Kuboyama T, Tohda C. Matrine promotes neural circuit remodeling to regulate motor function in a mouse model of chronic spinal cord injury. Neural Regeneration Research, 14(11), 1961-1967, 2019.
  • Yang Z, Kuboyama T†, Tohda C. Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression. Phytotherapy Research, 33(4), 1114–1121, 2019. †Corresponding author
  • Kuboyama T†. Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons. Journal of Visualized Experiments, 140: e58229, 2018. †Corresponding author
  • Tanie Y, Tanabe N, Kuboyama T, Tohda C. Extracellular Neuroleukin Enhances Neuroleukin Secretion From Astrocytes and Promotes Axonal Growth in vitro and in vivo. Frontiers in Pharmacology, 9:1228, 2018.
  • Tanabe N, Kuboyama T, Tohda C. Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-Mice. Frontiers in Pharmacology, 9:446, 2018.
  • Kuboyama T, Hirotsu K, Arai T, Yamasaki H, Tohda C. Polygalae Radix Extract Prevents Axonal Degeneration and Memory Deficits in a Transgenic Mouse Model of Alzheimer's Disease. Frontiers in Pharmacology, 8:805, 2017.
  • Kuboyama T, Wahane S, Huang Y, Zhou X, Wong JK, Koemeter-Cox A, Martini M, Friedel RH, Zou H. HDAC3 inhibition ameliorates spinal cord injury by immunomodulation. Scientific Reports, 7(1):8641, 2017.
  • Yang Z., Kuboyama T., Tohda C.: A Systematic Strategy for Discovering a Therapeutic Drug for Alzheimer’s Disease and Its Target Molecule. Frontiers in Pharmacology, 8: 340, 2017.
  • Tanabe N, Kuboyama T, Kazuma K, Konno K, Tohda C. The extract of roots of Sophora flavescens enhances the recovery of motor function by axonal growth in mice with a spinal cord injury. Frontiers in Pharmacology, 6:326, 2016.