研究室紹介

衛生化学分野

スタッフ

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スタッフ 主な担当科目 オフィスアワー
教授 戸田 晶久 (博士(薬学))

食品衛生学Ⅰ・Ⅱ
衛生薬学演習
(※公衆衛生学の内容も含む)
衛生薬学実習

月曜日・火曜日 13:00~17:00

不在の場合はメールで対応

准教授 副田 二三夫(博士(薬学))

環境衛生学Ⅰ・Ⅱ
衛生薬学演習
衛生薬学実習

木曜日 13:00~17:00

不在の場合はメールで対応

助教 古賀 貴之(博士(薬学)) 衛生薬学演習
衛生薬学実習

火曜日 14:00~17:00

不在の場合はメールで対応

研究内容
  • 化学物質による神経科学的検討と行動薬理学的研究
  • アレルギー疾患における生体内生理活性物質の役割
  • がん制御機構における乳酸菌の役割
  • 食品成分の排尿機能に対する作用とその作用機序に関する研究
  • QOL改善薬、特に排尿障害治療薬・予防薬の開発に関する研究
  • 環境因子(エンリッチ環境・非麻薬性中枢性鎮咳薬)の脳に対する作用とその作用機序に関する研究
  • POPsや内分泌撹乱物質の生体に及ぼす影響
  • 病棟に於ける様々な服薬指導業務の統計学的解析

代表論文

[原著論文]

  • Characterization of a Novel Allergenic Protein from the Octocoral Scleronephthya gracillima (Kuekenthal) which corresponds to a New GFP like protein named Akane, Kato Y, Jimbo M, Sakakibara Y, Onizuka R, Takahashi T, Matsuhashi S, Mita H, Amada K, Imahara Y, Tanabe K, Toda A, Kamiya H, Luminescence Sep. 2017, 32(6) 1009-1016.
  • Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration. Takeda T, Komiya Y, Koga T, Ishida T, Ishii Y, Kikuta Y, Nakaya M, Kurose H, Yokomizo T, Shimizu T, Uchi H, Furue M, Yamada H. J Biol Chem., 2017, 292:10586-10599.
  • α-Lipoic acid potentially targets AMP-activated protein kinase and energy production in the fetal brain to ameliorate dioxin-produced attenuation in fetal steroidogenesis. Takeda T, Matsuo Y, Nishida K, Fujiki A, Hattori Y, Koga T, Ishii Y, Yamada H. J Toxicol Sci., 2017, 42:13-23.
  • Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy. Koga T, Yao PL, Goudarzi M, Murray IA, Balandaram G, Gonzalez FJ, Perdew GH, Fornace AJ Jr, Peters JM. J Biol Chem., 2016, 291:25255-25263.
  • Centrally acting non-narcotic antitussives prevent hyperactivity in mice: Involvement of GIRK channels. Soeda F, Fujieda Y, Kinoshita M, Shirasaki T, Takahama K. Pharmacol Biochem Behav., 2016, 144:26-32.
  • Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Kawaura K, Ogata Y, Honda S, Soeda F, Shirasaki T, Takahama K. Behav Brain Res., 2016, 302: 269-278.
  • Cannabidiol-2’,6’-dimethyl ether stimulates body weight gain in apolipoprotein E-deficient BALB/c. KOR/Stm Slc- Apoe shl mice. Takeda S, Hirota R, Teradaira S, Takeda-Imoto M, Watanabe K, Toda A, Aramaki H. J Toxicol Sci., 2015, 40:739-743.
  • Effect of adenosine system in the action of oseltamivir on behavior in mice. Uchiyama H, Hiromura M, Shiratani T, Kuroki H, Honda S, Kosako K, Soeda S, Inoue K, Toda A. Neurosci Lett., 2015, 599:7-11.
  • Tipepidine increases dopamine level in the nucleus accumbens without methamphetamine-like behavioral sensitization. Hamao K, Kawaura K, Soeda F, Hamasaki R, Shirasaki T, Takahama K. Behav Brain Res., 2015, 284:118-124.
  • Novel antitussive effect of suplatast tosilate in guinea pigs. Zhou JR, Syono R, Fukumi S, Kimoto K, Shirasaki T, Soeda F, Takahama K. Pharmacology, 2015, 95: 36-41.
  • Recombinant fusion protein of cholera toxin B subunit with YVAD secreted by Lactobacillus casei inhibits lipopolysaccharide-induced caspase-1 activation and subsequent IL-1 beta secretion in Caco-2 cells. Hiramatsu Y, Yamamoto M, Satho T, Irie K, Kai A, Uyeda S, Fukumitsu Y, Toda A, Miyata T, Miake F, Arakawa T, Kashige N. BMC Biotechnology, 2014, 14:38.
  • Cloperastine rescues impairment of passive avoidance response in mice prenatally exposed to diethylstilbestrol. Soeda F, Hirakawa E, Inoue M, Shirasaki T, Takahama K. Environ Toxicol., 2014, 29:216-225.
  • Characterization of neural estrogen signaling and neurotrophic changes in the accelerated ovarian failure mouse model of menopause. Van Kempen TA, Gorecka J, Gonzalez AD, Soeda F, Milner TA, Waters EM. Endocrinology, 2014, 155:3610-3623.
  • Cholinergic EPSCs and their potentiation by bradykinin in single paratracheal ganglion neurons attached with presynaptic boutons. Zhou JR, Shirasaki T, Soeda F, Takahama K. J Neurophysiol., 2014, 112:933-941.
  • Role of the critical period in sex and brain differentiation: learning from dioxin-induced disorders in next generations. Yamada H, Takeda T, Koga T, Ishii Y. Yakugaku Zasshi. 2014, 134:529-35.
  • Expression and secretion of cholera toxin B subunit in lactobacilli. Okuno T, Kashige N, Satho T, Irie K, Hiramatsu Y, Sharmin T, Fukumitsu Y, Uyeda S, Yamada S, Harakuni T, Miyata T, Arakawa T, Imoto M, Toda A, Nakashima Y, Miake F. Biol Pharm Bull, 2013 ; 36: 952-958.
  • Pyriproxyfen enhances the Immunoglobulin G immune response in mice. Sharmin T, Satho T, Irie K, Watanabe M, Hosokawa M, Hiramatsu Y, Talukder P, Okuno T, Tsuruda S, Uyeda S, Fukmits Y, Tamura Y, Nakashima Y, Imoto M, Toda A, Kashige N, Miake F. Microbiol Immunol., 2013; 57: 316-322.
  • PPARβ/δ modulates ethanol-induced hepatic effects by decreasing pyridoxal kinase activity. Goudarzi M1, Koga T1, Khozoie C, Mak TD, Kang BH, Fornace AJ Jr and Peters JM. Toxicology, 2013; 311: 87-98.1Equally contributing authors.
  • Tipepidine activates VTA dopamine neuron via inhibiting dopamine D 2receptor-mediated inward rectifying K +current. Hamasaki R, Shirasaki T, Soeda F, Takahama K. Neuroscience, 2013, 252:24-34.
  • Effect of tipepidine with novel antidepressant-like action on c-fos-like protein expression in rat brain. Kawahara R, Soeda F, Kawaura K, Honda S, Miki R, Noguchi T, Shirasaki T, Takahama K. Brain Res., 2013, 1513:135-142.
  • Covalent binding of nitroso-sulfonamides to glutathione S-transferase in guinea pigs with delayed type hypersensitivity. Eyanagi R, Toda A, Imoto M, Uchiyama H, Ishii Y, Kuroki H, Kuramoto Y, Soeda S, Shimeno H. Int Immunopharmacol., 2012,; 12:694-700.
  • Vasohibin induces prolyl hydroxylase-mediated degradation of hypoxia-inducible factor-1α in human umbilical vein endothelial cells. Kozako T, Matsumoto N, Kuramoto Y, Sakata A, Motonagare R, Aikawa A, Imoto M, Toda A, Honda S, Shimeno H, Soeda S. FEBS Lett., 2012,; 586:1067-1072.
  • Restoration of dioxin-induced damage to fetal steroidogenesis and gonadotropin formation by maternal co-treatment with α-lipoic acid. Koga T, Ishida T, Takeda T, Ishii Y, Uchi H, Tsukimori K, Furue M, and Yamada H. PLOS ONE, 2012; 7: e40322.
  • Pharmacological mechanisms of antidepressant-like effect of tipepidine in the forced swimming test. Kawaura K, Miki R, Urashima Y, Kawahara R, Soeda F, Shirasaki T, Takahama K. Behav Brain Res., 2012; 226:381-385.
  • Δ9-tetrahydrocannabinol and its major metabolite Δ9-tetrahydrocannabinol-11-oic acid as 15-lipoxygenase inhibitors. Takeda S, Jiang R, Aramaki H, Imoto M, Toda A, Eyanagi R, Amamoto T, Yamamoto I, Watanabe K. J Pharm Sci., 2011,; 100:1206-1211.
  • The effect of aging and an ovariectomy operation on the level of phosphorylated CaM kinase II in the hippocampus of female mice prenatally exposed to diethylstilbestrol. Soeda F, Nagata M, Kaitsuka T, Shirasaki T, Takahama K. Environ Toxicol Pharmacol., 2011, 31:496-499.
  • Is the GIRK channel a possible target in the development of a novel therapeutic drug of urinary disturbance? Yamamoto G, Soeda F, Shirasaki T, Takahama K. Yakugaku Zasshi. 2011, 131:523-532.
  • Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test. Kawaura K, Miki R, Urashima Y, Honda S, Shehata AM, Soeda F, Shirasaki T, Takahama K. Eur J Pharmacol., 2011, 651:106-108.
  • The potent inhibitory effect of tipepidine on marble-burying behavior in mice. Honda S, Kawaura K, Soeda F, Shirasaki T, Takahama K. Behav Brain Res., 2011, 216:308-312.
  • Design, Synthesis, and Pharmacological Activity of Nonallergenic Pyrazolone-Type Antipyretic Analgesics. Uramaru N, Shigematsu H, Toda A, Eyanagi R, Kitamura S, Ohta S. J. Med. Chem., 2010; 53: 8727-8733
  • The stimulatory effects of caffeine with oseltamivir (Tamiflu®) on light-dark behavior and open field behavior in mice. Uchiyama H, Toda A, Imoto M, Nishimura S, Kuroki H, Soeda S, Shimeno H, Watanabe S, Eyanagi R. Neuroscience Lett., 2010; 469: 184-188
  • Antidepressant-like effect of centrally acting non-narcotic antitussive caramiphen in a forced swimming test. Kawaura K, Miki R, Shima E, Honda S, Soeda F, Shirasaki T, Takahama K. Neuroscience Lett., 2010, 481:188-190.
  • An enriched environment mitigates the brain-disruptive effects of prenatal diethylstilbestrol exposure in mice. Soeda F, Tanaka A, Shirasaki T, Takahama K. Neuroscience,2010, 169:223-228.
 
著書
  • 「衛生薬学 基礎・予防・臨床」編集/今井浩孝, 小椋康光:分担執筆/戸田晶久,南江堂, 東京(2016)
  • 「予防薬学としての衛生薬学−健康と環境− 第3版」監修/吉原新一,編集/山野茂,戸田晶久:分担執筆/戸田晶久 廣川書店, 東京(2016)
  • 「スタンダード薬学シリーズⅡ5;衛生薬学 健康と環境」編集/太田茂,原俊太郎,姫野誠一郎:分担執筆/戸田晶久,東京化学同人, 東京(2016)
  • 「コンパス衛生化学−健康と環境 − 第2版」編集/鍛冶利幸,佐藤雅彦:分担執筆/戸田晶久,南江堂, 東京(2016)
  • 「最新公衆衛生学 第6版」編集/上野仁, 小嶋仲夫, 中室克彦:分担執筆/戸田晶久,廣川書店, 東京(2015)
  • 「薬学のための医療統計学」編集/竹内正弘,細川友和,山村重雄:分担執筆/戸田晶久,廣川書店, 東京(2014)
  • 「予防薬学としての衛生薬学−健康と環境− 第2版」編集/吉原新一,山野茂,戸田晶久:分担執筆/戸田晶久,廣川書店, 東京(2012)
  • 「コンパス衛生化学−健康と環境−」編集/鍛冶利幸,佐藤雅彦:分担執筆/戸田晶久,南江堂, 東京(2011)
  • 「新 衛生化学・公衆衛生学」編集/大沢基保, 福井哲也, 永沼章:分担執筆/戸田晶久,南江堂, 東京(2011)
  • 「Pharmacology and Therapeutics of Cough」 Central Mechanism III: Neuronal mechanisms of action of centrally acting antitussives using electrophysiological and neurochemical study approaches. Editors: Kian Fan Chung, John Widdicombe; Authors: Takahama K, Shirasaki T, Soeda F. Springer Berlin Heidelberg (2009)
  • 「排尿障害プラクティス」脳梗塞に伴う排尿障害のGIRKチャネル阻害作用をもつ薬物による改善作用-動物モデルでの検討.高濱和夫, 山本巌, 門久大介, 白崎哲哉, 副田二三夫 15(4):38-43, メディカルレビュー社 (2008)
  • 「脳21-脳内GIRK チャネルとくすり-」高濱和夫, 白崎哲哉, 副田二三夫, 山本巌 9(3):90-96, 金芳堂 (2006)
連絡先

〒815-8511福岡市南区玉川町22-1
第一薬科大学 健康・環境衛生学講座
衛生化学分野
Tel.092-541-0161 Fax.092-553-5698
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戸田晶久 (384)
副田二三夫 (367)
古賀貴之 (366)