研究室紹介

和漢薬物学分野

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教授 森永 紀 (博士(薬学))

薬用資源学
生薬学

水曜日 13:00~17:00
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助教 小川 鶴洋(博士(薬学))

基礎実習
化学系実習

金曜日 13:00~17:00
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助手 大渡 勝史(農学修士)
(薬用植物園)

化学系実習

火曜日 13:00~17:00
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助手 増永 光恵(学士、栄養学)

   
研究内容
  • 生薬・漢方薬の効能および副作用に関する研究
  • 精油・香気性化合物の吸入投与による鎮静・摂食促進作用に関する研究
  • 伝統薬、OTC薬の科学的エビデンスに関する研究
  • 歴代公定書、教科書に記載される生薬の効能・効果に関する調査研究
  • 日、中、韓、朝、台の薬局方に関する調査研究
代表論文

(2016年―2019年6月まで)

2019年

  • Ishiuchi K, Morinaga O, Ohkita T, Tian C, Hirasawa A, Mitamura M, Maki Y, Kondo T, Yasujima T, Yuasa H, Minamizawa K, Namiki T, Makino T. 18β-glycyrrhetyl-3-O-sulfate would be a causative agent of licorice-induced pseudoaldosteronism. Scientific Reports, 9(1), 1587, 2019.
  • Ogawa K, Ito M. Appetite-enhancing effects of nutmeg oil and structure-activity relationship of habituation to phenylpropanoids. Journal of Natural Medicines, 73(3), 513-522, 2019.
  • Komatsu T, Katsuyama S, Takano F, Okamura T, Sakurada C, Tsuzuki M, Ogawa K, Kubota A, Morinaga O, Tabata K, Sakurada T. Possible involvement of the μ opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice. Neurosci Lett, 699, 103-108, 2019.

2018年

  • Ogawa K, Tashima A, Sadakata M, Morinaga O. Appetite-enhancing effects of vanilla flavours such as vanillin. Journal of Natural Medicines, 72(3), 798-802, 2018.
  • Morinaga O, Ishiuchi K, Ohkita T, Tian C, Hirasawa A, Mitamura M, Maki Y, Yasujima T, Yuasa H, Makino T. Isolation of a novel glycyrrhizin metabolite as a causal candidate compound for pseudoaldosteronism.Scientific Reports, 8(1), 15568, 2018.
  • Morinaga O. Scientific Evaluation of Crude Drugs and Kampo Medicines Using the Eastern Blotting Method and Its Application to Biological Metabolic Studies. Yakugaku Zasshi, 138(6), 743-750, 2018.

2017年

  • Ogawa Y. Morinaga O, Yahagi N, Yahagi R, Kobayashi H. Ophiocordyceps pulvinata Induces Caspase-Dependent Apoptosis through Mitochondrial Impairment in Human Leukemia Cells. Int. J. Curr. Microbiol. App. Sci, 6(1), 579-591, 2017.
  • Fujii S, Morinaga O, Uto T, Nomura S, Shoyama Y. Simultaneous determination of glycyrrhizin and liquiritin in licorice roots and Kampo medicines by combination enzyme-linked immunosorbent assay using anti-glycyrrhizin and anti-liquiritin monoclonal antibodies. J Immunoassay Immunochem, 1-14, 2016.
  • 矢作忠弘,石内勘一郎,渥美聡孝,三宅克典,森永 紀,伏見裕利,大山雅義,森川敏生,田中 謙,有田正規,牧野利明:歴代教科書・解説書に見られる生薬の効能に関する記載のデータベース化(1),生薬学雑誌;71:1–19, 2017.
  • 矢作忠弘,石内勘一郎,渥美聡孝,三宅克典,森永 紀,伏見裕利,大山雅義,森川敏生,田中 謙,有田正規,牧野利明:歴代教科書・解説書に見られる生薬の効能に関する記載のデータベース化(2),生薬学雑誌;71:20–36, 2017.
  • 岡崎啓介,山田春樹,森永 紀:大黄・センナ含有医薬品のセンノシドA・B定量による刺激性下剤成分の評価,兵庫県医師会医学雑誌,第59巻2号:32-36,2017.

2016年

  • Ogawa K, Yabe H, Kitayama T, Ito M. Locomotor-Reducing Activity of Sesquiterpenes Related to Zingiber zerumbet Essential Oil and Hexahydrozerumbone Derivatives. Biol Pharm Bull, 39(6), 1077-80,2016.
  • Ogawa K, Ito M. Appetite-Enhancing Effects: The Influence of Concentrations of Benzylacetone and trans-Cinnamaldehyde and Their Inhalation Time, as Well as the Effect of Aroma, on Body Weight in Mice. Biol Pharm Bull, 39(5), 794-798,2016.
  • Ogawa K, Ito M. Appetite-enhancing Effects of trans-Cinnamaldehyde, Benzylacetone and 1-Phenyl-2-butanone by Inhalation. Planta Med, 82(1-2), 84-88,2016.
  • Ogawa K, Ito M. Appetite-Enhancing Effects of Curry Oil. Biol Pharm Bull, 39(9) 1559-1563,2016.
  • Kwofie KD, Tung NH, Suzuki-Ohashi M, Amoa-Bosompem M, Adegle R, Sakyiamah MM, Ayertey F, Owusu KB, Tuffour I, Atchoglo P, Frempong KK, Anyan WK, Uto T, Morinaga O, Yamashita T, Aboagye F, Appiah AA, Appiah-Opong R, Nyarko AK, Yamaguchi Y, Edoh D, Koram KA, Yamaoka S, Boakye DA, Ohta N, Shoyama Y, Ayi I. Antitrypanosomal Activities and Mechanisms of Action of Novel Tetracyclic Iridoids from Morinda lucida Benth. Antimicrob Agents Chemother,60(6), 3283-3290,2016.
  • Fujii S, Morinaga O, Uto T, Nomura S, Shoyama Y. Development of Double Eastern Blotting for Major Licorice Components, Glycyrrhizin and Liquiritin for Chemical Quality Control of Licorice Using anti-Glycyrrhizin and anti-Liquiritin Monoclonal Antibodies. J Agric Food Chem,64(5), 1087-1093,2016.
  • Owusu KB, Tuffour I, Atchoglo P, Djameh GI, Azerigyik FA, Botchie SK, Anyan WK, Appiah-Opong R, Uto T, Morinaga O, Appiah AA, Ayi I, Shoyama Y, Boakye DA, Ohta N. In vitro anti-Leishmania activity of tetracyclic iridoids from Morinda lucida, benth. Tropical Medicine and Health, 44: 25, 1-5, 2016.
  • Nakajima K, Oiso S, Uto T, Morinaga O, Syoyama Y, Kariyazono H. Triterpenes suppress octanoylated ghrelin production in ghrelin-expressing human gastric carcinoma cells. Biomed Res.,37(6), 343-349, 2016.