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分析化学分野

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教授 藤井 清永 (博士(薬学)) 分析化学Ⅲ
構造解析演習
物理系実習
基礎実習
木曜日 13:30~16:30
不在の場合はメールにて対応
講師 藤井由希子 (博士(社会健康医学)) 物理系演習
物理系実習
基礎実習
月曜日 14:45~16:15
不在の場合はメールにて対応
研究内容
  • 分析化学、特に分離分析、質量分析に特化して、生体分子や医薬品に対する分析手法の開発とその応用を試みています。
  • 環境有害物質の分析を通じて、ヒトへの暴露評価や環境モニタリングを試みています。
代表論文

【2020】

  • Lactational transfer of long-chain perfluorinated carboxylic acids in mice: A method to directly collect milk and evaluate chemical transferability. Fujii Y, Harada KH, Kobayashi H, Haraguchi K, Koizumi A.Toxics. 2020 Apr 1;8(2):23.
  • Analysis of perfluorooctanesulfonate isomers and other perfluorinated alkyl acids in serum by in-port arylation gas chromatography negative chemical ionization-mass spectrometry.Harada KH, Fujii Y, Zhu J, Zheng B, Cao Y, Hitomi T.Environ Sci Technol Lett. 2020 Apr 14;7(4):259-265.
  • Levels of octachlorostyrene in mothers' milk and potential exposure among infants in Sendai city, Japan 2012.Soleman SR, Fujitani T, Fujii Y, Harada KH. Int J Environ Res Public Health. 2020 Apr 28;17(9):3064.
  • Disease-related cellular protein networks differentially affected under different EGFR mutations in lung adenocarcinoma. Nishimura T, Nakamura H, Yachie A, Hase T, Fujii K, Koizumi H, Naruki S, Takagi M, Matsuoka Y, Furuya N, Kato H, Saji H. Sci Rep. 2020 Jul 2;10(1):10881.
  • A proteogenomic profile of early lung adenocarcinomas by protein co-expression network and genomic alteration analysis. Nishimura T, Nakamura H, Tan KT, Zhuo DW, Fujii K, Koizumi H, Naruki S, Takagi M, Furuya N, Kato Y, Chen SJ, Kato H, Saji H. Sci Rep. 2020 Aug 12;10(1):13604.
  • Perfluorinated carboxylic acids in edible clams: A possible exposure source of perfluorooctanoic acid for Japanese population. Fujii Y, Harada KH, Nakamura T, Kato Y, Ohta C, Koga N, Kimura O, Endo T, Koizumi A, Haraguchi K. Environ Pollut. 2020 Aug;263:114369.
  • Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells. Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T. Biochem Biophys Rep. 2020 Sep 7;24:100807.
 

【2019】

  • Emergence of the dedifferentiated phenotype in hepatocyte-derived tumors in mice: roles of oncogene-induced epigenetic alterations. Watanabe K, Yamamoto M, Xin B, Ooshio T, Goto M, Fujii K, Liu Y, Okada Y, Furukawa H, Nishikawa Y. Hepatol Commun. 2019 Feb 25;3(5):697-715.
  • Levels and profiles of long-chain perfluoroalkyl carboxylic acids in Pacific cod from 14 sites in the North Pacific Ocean.Fujii Y, Tuda H, Kato Y, Kimura O, Endo T, Harada KH, Koizumi A, Haraguchi K. Environ Pollut. 2019 Apr;247:312-318.
  • Identification of key modules and hub genes for small-cell lung carcinoma and large-cell neuroendocrine lung carcinoma by weighted gene co-expression network analysis of clinical tissue-proteomes. Nakamura H, Fujii K, Gupta V, Hata H, Koizumu H, Hoshikawa M, Naruki S, Miyata Y, Takahashi I, Miyazawa T, Sakai H, Tsumoto K, Takagi M, Saji H, Nishimura T. PLoS One. 2019 Jun 5;14(6):e0217105.
  • Assessment of diabetics by the quantification of essential elements and stable isotope ratios of carbon and nitrogen in scalp hair. Hotta Y, Fujino R, Kimura O, Fujii Y, Haraguchi K, Endo T. Obesity Medicine 2019 Sept;15:100-106.
  • Kanechlor 500-mediated changes in serum and hepatic thyroxine levels primarily occur in a transthyretin-unrelated manner. Kato Y, Tamaki S, Haraguchi K, Ikushiro SI, Fujii Y, Ohta C, Atobe K, Kimura O, Endo T, Koga N, Yamada S, Degawa M. J Appl Toxicol. 2019 Dec;39(12):1701-1709.
  • Occurrence of selected organic contaminants in edible insects and assessment of their chemical safety. Poma G, Yin S, Tang B, Fujii Y, Cuykx M, Covaci A. Environ Health Perspect. 2019 Dec;127(12):127009.
  • 2,2',3,4',5,6,6'-七塩素化ビフェニル(CB188)のラットおよびモルモット肝ミクロゾームによる代謝 太田 千穂、山本 健太、加藤 善久、藤井 由希子、原口 浩一、木村 治、遠藤 哲也、古賀 信幸 福岡医学雑誌 2019, 110, 83-90.