科目ごとのオフィスアワーはシラバスを確認してください

1. 難治性神経疾患（アルツハイマー病、不安障害など）のモデル細胞系・動物系の確立と、それらに対して有効な漢方薬・生薬の探索
2. 記憶向上作用を有する漢方薬・生薬の探索
3. 上記漢方薬・生薬の薬理作用の解明と、難治性神経疾患の根本的治療法の提唱
4. 新たな機能性を有した食品の開発
5. 薬用植物、機能性作物の栽培方法の最適化

久保山

1. Chino K, Izuo N, Noike H, Uno K, Kuboyama T, Tohda C, Muramatsu SI, Nitta A. Shati/Nat8l Overexpression Improves Cognitive Decline by Upregulating Neuronal Trophic Factor in Alzheimer’s Disease Model Mice. Neurochemical Research, 47(9):2805-2814, 2022.
2. Kuboyama T†, Kominato S, Nagumo M, Tohda C. Recovery from spinal cord injury via M2 microglial polarization induced by Polygalae Radix. Phytomedicine, 82:153452, 2021. †Corresponding author
3. Farid MM, Yang X, Kuboyama T, Tohda C. Trigonelline recovers memory function in Alzheimer’s disease model mice: evidence of brain penetration and target molecule. Scientific Reports, 10(1):16424, 2020
4. Tohda C, Matsui M, Inada Y, Yang X, Kuboyama T, Kimbara Y, Watari H. Combined Treatment with Two Water Extracts of Eleutherococcus senticosus Leaf and Rhizome of Drynaria fortunei Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults. Nutrients , 12, 303, 2020.
5. Tanabe N, Kuboyama T, Tohda C. Matrine promotes neural circuit remodeling to regulate motor function in a mouse model of chronic spinal cord injury. Neural Regeneration Research, 14(11), 1961-1967, 2019.
6. Yang Z, Kuboyama T†, Tohda C. Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression. Phytotherapy Research, 33(4), 1114–1121, 2019. †Corresponding author
7. Kuboyama T†. Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons. Journal of Visualized Experiments, 140: e58229, 2018. †Corresponding author
8. Tanie Y, Tanabe N, Kuboyama T, Tohda C. Extracellular Neuroleukin Enhances Neuroleukin Secretion From Astrocytes and Promotes Axonal Growth in vitro and in vivo. Frontiers in Pharmacology, 9:1228, 2018.
9. Tanabe N, Kuboyama T, Tohda C. Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-Mice. Frontiers in Pharmacology, 9:446, 2018.
10. Kuboyama T, Hirotsu K, Arai T, Yamasaki H, Tohda C. Polygalae Radix Extract Prevents Axonal Degeneration and Memory Deficits in a Transgenic Mouse Model of Alzheimer’s Disease. Frontiers in Pharmacology, 8:805, 2017.
11. Kuboyama T, Wahane S, Huang Y, Zhou X, Wong JK, Koemeter-Cox A, Martini M, Friedel RH, Zou H. HDAC3 inhibition ameliorates spinal cord injury by immunomodulation. Scientific Reports, 7(1):8641, 2017.
12. Yang Z., Kuboyama T., Tohda C.: A Systematic Strategy for Discovering a Therapeutic Drug for Alzheimer’s Disease and Its Target Molecule. Frontiers in Pharmacology, 8: 340, 2017.
13. Tanabe N, Kuboyama T, Kazuma K, Konno K, Tohda C. The extract of roots of Sophora flavescens enhances the recovery of motor function by axonal growth in mice with a spinal cord injury. Frontiers in Pharmacology, 6:326, 2016.