教育・研究活動研究室紹介

薬学部医薬品化学・物性学講座生薬学分野

スタッフ

科目ごとのオフィスアワーはシラバスを確認してください

スタッフ 主な担当科目 オフィスアワー
准教授 久保山 友晴 (博士 (薬学))
(研究室主任)
本草学
漢方・民間薬概論
物理系実習
伝統医療薬学実習
水曜日 15:00~17:00
不在の場合はメールにて対応
助手 大渡 勝史(農学修士)
(薬用植物園)
化学系実習 火曜日 13:00~17:00
不在の場合はメールにて対応
研究内容
  1. 難治性神経疾患(アルツハイマー病、不安障害など)のモデル細胞系・動物系の確立と、それらに対して有効な漢方薬・生薬の探索
  2. 上記漢方薬・生薬の薬理作用の解明と、難治性神経疾患の根本的治療法の提唱
  3. 新たな機能性を有した食品の開発
  4. 薬用植物、機能性作物の栽培方法の最適化
代表論文

久保山

  1. Chino K, Izuo N, Noike H, Uno K, Kuboyama T, Tohda C, Muramatsu SI, Nitta A. Shati/Nat8l Overexpression Improves Cognitive Decline by Upregulating Neuronal Trophic Factor in Alzheimer’s Disease Model Mice. Neurochemical Research, in press
  2. Kuboyama T†, Kominato S, Nagumo M, Tohda C. Recovery from spinal cord injury via M2 microglial polarization induced by Polygalae Radix. Phytomedicine, 82:153452, 2021. †Corresponding author
  3. Farid MM, Yang X, Kuboyama T, Tohda C. Trigonelline recovers memory function in Alzheimer’s disease model mice: evidence of brain penetration and target molecule. Scientific Reports, 10(1):16424, 2020
  4. Tohda C, Matsui M, Inada Y, Yang X, Kuboyama T, Kimbara Y, Watari H. Combined Treatment with Two Water Extracts of Eleutherococcus senticosus Leaf and Rhizome of Drynaria fortunei Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults. Nutrients 2020, 12, 303.
  5. Tanabe N, Kuboyama T, Tohda C. Matrine promotes neural circuit remodeling to regulate motor function in a mouse model of chronic spinal cord injury. Neural Regeneration Research, 14(11), 1961-1967, 2019.
  6. Yang Z, Kuboyama T†, Tohda C. Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression. Phytotherapy Research, 33(4), 1114–1121, 2019. †Corresponding author
  7. Kuboyama T†. Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons. Journal of Visualized Experiments, 140: e58229, 2018. †Corresponding author
  8. Tanie Y, Tanabe N, Kuboyama T, Tohda C. Extracellular Neuroleukin Enhances Neuroleukin Secretion From Astrocytes and Promotes Axonal Growth in vitro and in vivo. Frontiers in Pharmacology, 9:1228, 2018.
  9. Tanabe N, Kuboyama T, Tohda C. Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-Mice. Frontiers in Pharmacology, 9:446, 2018.
  10. Kuboyama T, Hirotsu K, Arai T, Yamasaki H, Tohda C. Polygalae Radix Extract Prevents Axonal Degeneration and Memory Deficits in a Transgenic Mouse Model of Alzheimer’s Disease. Frontiers in Pharmacology, 8:805, 2017.
  11. Kuboyama T, Wahane S, Huang Y, Zhou X, Wong JK, Koemeter-Cox A, Martini M, Friedel RH, Zou H. HDAC3 inhibition ameliorates spinal cord injury by immunomodulation. Scientific Reports, 7(1):8641, 2017.
  12. Yang Z., Kuboyama T., Tohda C.: A Systematic Strategy for Discovering a Therapeutic Drug for Alzheimer’s Disease and Its Target Molecule. Frontiers in Pharmacology, 8: 340, 2017.
  13. Tanabe N, Kuboyama T, Kazuma K, Konno K, Tohda C. The extract of roots of Sophora flavescens enhances the recovery of motor function by axonal growth in mice with a spinal cord injury. Frontiers in Pharmacology, 6:326, 2016.

Link関連リンク

  • 薬学部 薬学科
  • 薬学部 漢方薬学科
  • 看護学部 看護学科
  • 大学案内
  • キャンパス・学生生活
  • 受験生応援サイト