教育・研究活動教員紹介

中原 広道

中原 広道NAKAHARA Hiromichi

薬学部 薬科学科／薬剤設計学分野

  • 学位

    博士（薬学）

  • 免許・資格

    薬剤師

  • 所属学会

    日本薬学会、日本油化学会、日本化学会界面科学部会

  • 専門分野

    界面科学、物理薬剤学

  • 研究テーマ

    ・肺サーファクタントに関する界面科学的研究
    ・生体膜成分と薬物及びそのモデル化合物の相互作用に関する界面科学的研究
    ・難溶性化合物の可溶化に関する研究

業績

  • （著書）

    1. 中原　広道，洗浄の事典, 1-27 ミセル形成、　6-7　cmc/クラフト点測定，朝倉書店，2022年10月1日，pp62−63，pp434−435，ISBN 978-4-254-25273-6、pp1−560.

    2. 中原　広道，界面活性剤の選び方、使い方 事例集, 第5章 第3節　界面活性剤ミセルへの可溶化挙動解析，技術情報協会，2019年7月31日，pp253−261，ISBN978-4-86104-753-4.

    3. 中島　俊男，脇　　博彦，中原　広道，柴田　　攻, 溶存状態の分析化学, 長崎国際大学，2014年9月1日，pp1−130，ISBN978-4-904962-04-6.

    4. 師井　義清，中原　広道，柴田　　攻, 界面活性剤の物理化学　理論と現象そして新概念,長崎国際大学，2013年9月10日，pp1−211，ISBN978-4-904962-03-9.

  • （原著論文）

    1. 中原　広道, Langmuir単分子膜手法によるテトラジン誘導体と生体膜構成脂質との相互作用, Colloid & Interface Communication 48(1) (2023)23-26.

    2. Inverse electron-demand Diels-Alder reactions of tetrazine and norbornene at the air-water interface, Hiromichi Nakahara, Masayori Hagimori, Kento Kannaka, Takahiro Mukai, Osamu Shibata, Colloids Surf. B Biointerfaces 211 (2022) 112333, DOI: 10.1016/j.colsurfb.2022.112333.

    3. Interplay of long-chain tetrazine derivatives and biomembrane components at the air–water interface, Hiromichi Nakahara, Masayori Hagimori, Takahiro Mukai, Osamu Shibata, Biophysics Rev. 3 (2022) 021303, DOI: 10.1063/5.0083352.

    4. Ionic distribution of MgCl2 near the alcohol/water interface, Cuong V. Nguyen, Chi M. Phan, Hiromichi Nakahara, Osamu Shibata, J. Mol. Liq. 344 (2021) 117902, DOI: 10.1016/j.molliq.2021.117902.

    5. Adsorption of sodium iodine at air/water interface, Cuong V. Nguyen, Hiromichi Nakahara, Osamu Shibata, Chi M. Phan, J. Mol. Liq. 298 (2020) 112076, DOI: 10.1016/j.molliq.2019.112076.

    6. Solubilization of progesterone and its derivatives into gemini surfactant solutions, Hiroki Ideguchi, Yuya Takasaki, Shintaro Kondo, Mai Nakanose, Nana Teradahira, Yumeka Yamamoto, Umi Mouri, Hiromichi Nakahara, J. Oleo Sci. 69 (2020) 557-562, DOI: 10.5650/jos.ess20007.

    7. Surface potential of the air/water interface, Cuong V. Nguyen, Hiromichi Nakahara, Chi M. Phan, J. Oleo Sci. 69 (2020) 519-528, DOI: 10.5650/jos.ess20024.

    8. How self-assembled nanodomains can impact the organization of a phospholipid monolayer: flower-like arrays, Hiromichi Nakahara, Marie Pierre Krafft, Osamu Shibata, ChemPhysChem 21 (2020) 1966-1970, DOI: 10.1002/cphc.202000496.

    9. Inverse electron demand Diels–Alder reactions in the liposomal membrane accelerates release of the encapsulated drugs, Kento Kannaka, Kohei Sano, Hiromichi Nakahara, Masayuki Munekane, Masayori Hagimori, Toshihide Yamasaki, Takahiro Mukai, Langmuir 36 (2020) 10750-10755, DOI: 10.1021/acs.langmuir.0c01525.

    10. Fluidity of binary monolayers of semi-fluorinated and non-fluorinated fatty alcohols at the air−water interface, Hiromichi Nakahara, Muneaki Minamisono, Osamu Shibata, J. Fluorine Chem. 228 (2019) 109408, DOI: 10.1016/j.jfluchem.2019.109408.

    11. Lateral interaction of cholesterol with a semifluorinated amphiphile at the air–water interface, Hiromichi Nakahara, Muneaki Minamisono, Osamu Shibata, Colloids Surf. B Biointerfaces 181 (2019) 1035−1040, DOI: 10.1016/j.colsurfb.2019.06.072.

    12. Interfacial behavior of gemini surfactants with different spacer lengths in aqueous medium, Hiromichi Nakahara, Ayami Nishino, Ayaka Tanaka, Yoshika Fujita, Osamu Shibata, Colloid Polym. Sci. 297 (2019) 183−189, DOI: 10.1007/s00396-018-4459-8.

    13. Miscibility of semifluorinated pentadecanol with DPPC at the air−water interface, Hiromichi Nakahara, Osamu Shibata, Acc. Mater. Surf. Res. 3 (2018) 199−208.

    14. Monolayers of a tetrazine-containing gemini amphiphile: Interplays with biomembrane lipids, Hiromichi Nakahara, Masayori Hagimori, Takahiro Mukai, Osamu Shibata, Colloids Surf. B Biointerfaces 164 (2018) 1−10, DOI: 10.1016/j.colsurfb.2018.01.015.

    15. Surface structure of sodium chloride solution, Cuong V. Nguyen, Chi M. Phan, Hiromichi Nakahara, Osamu Shibata, J. Mol. Liq. 248 (2017) 1039–1043, DOI: 10.1016/j.molliq.2017.10.138.

    16. Role of the spacer of Gemini surfactants in solubilization into their micelles, Hiromichi Nakahara, Hiroaki Nishizaka, Kensuke Iwasaki, Yu Otsuji, Mika Sato, Keisuke Matsuoka, Osamu Shibata, J. Mol. Liq. 244 (2017) 499−505, DOI: 10.1016/j.molliq.2017.09.014.

    17. Interplay of Hydrophobic and Electrostatic Interactions between Polyoxometalates and Lipid Molecules, Daiki Kobayashi, Hiromichi Nakahara, Osamu Shibata, Kei Unoura, Hideki Nabika, J. Phys. Chem. C 121 (2017) 12895−12902, DOI: 10.1021/acs.jpcc.7b01774.

    18. Interfacial Properties of Binary Systems Composed of DPPC and Perfluorinated Double Long-Chain Salts with Divalent Counterions of Separate Electric Charge, Riku Kato, Hiromichi Nakahara, Osamu Shibata, J. Oleo Sci. 66 (2017) 479−489, DOI: 10.5650/jos.ess16208.

    19. Galactosidase Langmuir Monolayer at Air/X-gal Subphase Interface, Shiv K. Sharma, Shanghao Li, Miodrag Micic, Jhony Orbulescu, Daniel Weissbart, Hiromichi Nakahara, Osamu Shibata, and Roger M. Leblanc, J. Phys. Chem. B 120 (2016) 12279−12286, DOI: 10.1021/acs.jpcb.6b09020.

    20. Ionic Nature of a Gemini Surfactant at the Air/Water Interface, Chi M. Phan, Cuong V. Nguyen, Hiromichi Nakahara, Osamu Shibata, and Thanh V. Nguyen, Langmuir 32 (2016) 12842−12847, DOI: 10.1021/acs.langmuir.6b03484.

    21. Interfacial Phenomena of Pulmonary Surfactant Preparations, Hiromichi Nakahara, Sannamu Lee, and Osamu Shibata, In Encyclopedia of Biocolloid and Biointerface Science, Hiroyuki Ohshima, Ed., Wiley Inc., 2016, pp885-904, ISBN: 978-1-118-54276-7.

    22. Langmuir Monolayer Interaction of Perfluorooctylated Long-Chain Alcohols with Biomembrane Constituents, Hiromichi Nakahara and Osamu Shibata, In Encyclopedia of Biocolloid and Biointerface Science, Hiroyuki Ohshima, Ed., Wiley Inc., 2016, pp597-608, ISBN: 978-1-118-54276-7.

    23. Interactions of a Tetrazine Derivative with Biomembrane Constituents: A Langmuir Monolayer Study, Hiromichi Nakahara, Masayori Hagimori, Takahiro Mukai, Osamu Shibata, Langmuir 32 (2016) 6591−6599, DOI: 10.1021/acs.langmuir.6b00997.

    24. Thermodynamic Model of Charging the Gas/Water Interface, Nikola Kallay, Tajana Preočanin, Atiđa Selmani, Davor Kovačević, Johannes Lützenkirchen, Hiromichi Nakahara, Osamu Shibata, The Journal of Physical Chemistry C 119 (2015) 997−1007, DOI: 10.1021/jp507477u.

    25. Molecular Dynamics Investigation on Adsorption Layer of Alcohols at the Air/Brine Interface, Cuong V. Nguyen, Chi M. Phan, Ha M. Ang, Hiromichi Nakahara, Osamu Shibata, Yoshikiyo Moroi, Langmuir 31 (2015) 50−56, DOI: 10.1021/la504471q.

    26. Effect of Serum, Cholesterol and Low Density Lipoprotein on the Functionality and Structure of Lung Surfactant Films, Prasant Nahak, Kaushik Nag, Ashley Hillier, Ravi Devraj, David W. Thompson, Kausik Manna, Kimiko Makino, Hiroyuki Ohshima, Hiromichi Nakahara, Osamu Shibata, Amiya Kumar Panda, Journal of Oleo Science 63 (2014) 1333−1349, DOI: 10.5650/jos.ess14071.

    27. Interfacial Behavior of Pulmonary Surfactant Preparations Containing Egg Yolk Lecithin, Hiromichi Nakahara, Osamu Shibata, Journal of Oleo Science 63 (2014) 1159−1168, DOI: 10.5650/jos.ess14105.

    28. Impairing Effect of Fibrinogen on the Mono-/Bi-layer Form of Bovine Lung Surfactant, Ravi Devraj, Kaushik Nag, Prasant Nahak, Kausik Manna, Mauricia Fritzen-Garcia, David W. Thompson, Kimiko Makino, Hiroyuki Ohshima, Hiromichi Nakahara, Osamu Shibata, Amiya Kumar Panda, Colloid and Polymer Science 292 (2014) 2765–2774, DOI: 10.1007/s00396-014-3319-4.

    29. Solubilization of n-Alkylbenzenes into Gemini Surfactant Micelles in Aqueous Medium, Hiromichi Nakahara, Yui Kojima, Yoshikiyo Moroi, Osamu Shibata, Langmuir 30 (2014) 5771–5779, DOI: 10.1021/la501519a.

    30. Improvement of Pulmonary Surfactant Activity by Introducing D-Amino Acids into Highly Hydrophobic Amphiphilic α-Peptide Hel 13-5, Yoshihiro Nakamura, Ko Yukitake, Hiromichi Nakahara, Sooyoung Lee, Osamu Shibata, Sannamu Lee, Biochimica et Biophysica Acta (BBA) – Biomembranes 1838 (2014) 2046–2052, DOI: 10.1016/j.bbamem.2014.04.024.

    31. Two-Component Langmuir Monolayers and LB Films of DPPC with Partially Fluorinated Alcohol (F8H9OH), Hiromichi Nakahara, Chikayo Hirano, Osamu Shibata, Journal of Oleo Science 62 (2013) 1029-1039, DOI: 10.5650/jos.62.1029.

    32. Interfacial Properties in Langmuir Monolayers and LB Films of DPPC with Partially Fluorinated Alcohol (F8H7OH), Hiromichi Nakahara, Chikayo Hirano, Ichiro Fujita, Osamu Shibata, Journal of Oleo Science 62 (2013) 1017-1027, DOI: 10.5650/jos.62.1017.

    33. Solution Properties of Gemini Surfactant of Decanediyl-1-10-bis(dimethyltetradecylammonium bromide) in Aqueous Medium, Hiromichi Nakahara, Atsuko Hasegawa, Seina Uehara, Hideo Akisada, Osamu Shibata, Journal of Oleo Science 62 (2013) 905–912, DOI: 10.5650/jos.62.905.

    34. Seiichi Sakamoto, Hiromichi Nakahara, Osamu Shibata, Miscibility Behavior of Sphingomyelin with Phytosterol Derivatives by a Langmuir Monolayer Approach, Journal of Oleo Science 62 (2013) 809–824, DOI: 10.5650/jos.62.809.

    35. Surface Potential of 1-Hexanol Solution: Comparison with Methyl Isobutyl Carbinol, Cuong V. Nguyen, Chi M. Phan, Ha M. Ang, Hiromichi Nakahara, Osamu Shibata, Yoshikiyo Moroi, The Journal of Physical Chemistry B 117 (2013) 7615–7620, DOI: 10.1021/jp4027157.

    36. Miscibility of Egg Yolk Lecithin with Palmitic Acid and Hexadecanol at the Air-Water Interface, Hiromichi Nakahara, Osamu Shibata, Journal of Oleo Science 62 (2013) 471–480, DOI: 10.5650/jos.62.471.

    37. Monolayer Compression Induces Fluidization in Binary System of Partially Fluorinated Alcohol (F4H11OH) with DPPC, Hiromichi Nakahara, Aya Ohmine, Shoko Kai, Osamu Shibata, Journal of Oleo Science 62 (2013) 271–281, DOI: 10.5650/jos.62.271.

    38. Investigation of Interfacial Behavior of Glycyrrhizin with a Lipid Raft Model via a Langmuir Monolayer Study, Seiichi Sakamoto, Hiromichi Nakahara, Takuhiro Uto, Yukihiro Shoyama, Osamu Shibata, Biochimica et Biophysica Acta (BBA) – Biomembranes 1828 (2013) 1271–1283, DOI: 10.1016/j.bbamem.2013.01.006.

    39. Surface Pressure Induced Structural Transitions of an Amphiphilic Peptide in Pulmonary Surfactant Systems by an In Situ PM-IRRAS Study, Hiromichi Nakahara, Sannamu Lee, Osamu Shibata, Biochimica et Biophysica Acta (BBA) – Biomembranes 1828 (2013) 1205–1213, DOI: 10.1016/j.bbamem.2013.01.003.

    40. Examination of Fluorination Effect on Physical Properties of Saturated Long-Chain Alcohols by DSC and Langmuir Monolayer, Hiromichi Nakahara, Shohei Nakamura, Yoshinori Okahashi, Daisuke Kitaguchi, Noritake Kawabata, Seiichi Sakamoto, Osamu Shibata, Colloids and Surfaces B: Biointerfaces 102 (2013) 472– 478, DOI: 10.1016/j.colsurfb.2012.08.031.

    41. Fluobodies Against Bioactive Natural Products and Their Application in Fluorescence-Linked Immunosorbent Assay, Seiichi Sakamoto, Benyakan Pongkitwitoon, Hiromichi Nakahara, Osamu Shibata, Yukihiro Shoyama, Hiroyuki Tanaka, Satoshi Morimoto, Antibodies 1 (2012)239–258, DOI: 10.3390/abtib1020239.

    42. A Study on Novel Artificial Lung Surfactants Incorporated with Partially Fluorinated Amphiphiles, Hiromichi Nakahara, YAKUGAKU ZASSHI 132 (2012) 817–822, https://www.jstage.jst.go.jp/article/yakushi/132/7/132_ 132.817/_ article/-char/ja/.

    43. Surface Potential of Methyl Isobutyl Carbinol Adsorption Layer at the Air/Water Interface, Chi M. Phan, Hiromichi Nakahara, Osamu Shibata, Yoshikiyo Moroi, Thu N. Le, Ha M. Ang, The Journal of Physical Chemistry B 116 (2012) 980–986, DOI: 10.1021/jp210053u.

    44. The Role of Palmitic Acid in Pulmonary Surfactant Systems by Langmuir Monolayer Study: Lipid–Peptide Interactions, Hiromichi Nakahara, Sannamu Lee, Yukihiro Shoyama, Osamu Shibata, Soft Matter 7(2011)11351–11359, DOI: 10.1039/c1sm06345f.

    45. Interaction of a Partially Fluorinated Alcohol (F8H11OH) with Biomembrane Constituents in Two-Component Monolayers, Hiromichi Nakahara, Marie Pierre Krafft, Akira Shibata, Osamu Shibata, Soft Matter 7(2011)7325–7333 (Hot Article), DOI: 10.1039/c1sm05647fp.

    46. Examination of Surface Adsorption of Cetyltrimethylammonium Bromide and Sodium Dodecyl Sulfate, Hiromichi Nakahara, Osamu Shibata, Yoshikiyo Moroi, The Journal of Physical Chemistry B 115(2011)9077–9086, DOI: 10.1021/jp202940p.

    47. Fluorocarbon-Hybrid Pulmonary Surfactants for Replacement Therapy – A Langmuir Monolayer Study, Hiromichi Nakahara, Sannamu Lee, Marie Pierre Krafft, Osamu Shibata, Langmuir 26(2010)18256–18265, DOI: 10.1021/la103118d.

    48. Specific Interaction Restrains Structural Transitions of an Amphiphilic Peptide in Pulmonary Surfactant Model Systems: An In Situ PM-IRRAS Investigation, Hiromichi Nakahara, Sannamu Lee, Osamu Shibata, Biochimica et Biophysica Acta (BBA) – Biomembranes 1798(2010)1263–1271, DOI: 10.1016/j.bbamem.2010.02.018.

    49. Miscibility and Phase Behavior of DPPG and Perfluorocarboxylic Acids at the Air–Water Interface, Hiroki Yokoyama, Hiromichi Nakahara, Osamu Shibata, Chemistry and Physics of Lipids 161 (2009) 103–114, DOI: 10.1016/j.chemphyslip.2009.06.142.

    50. Langmuir Monolayer Miscibility of Single-Chain Partially Fluorinated Amphiphiles with Tetradecanoic Acid, Hiromichi Nakahara, Minami Tsuji, Yukiko Sato, Marie Pierre Krafft, Osamu Shibata, Journal of Colloid and Interface Science 337(2009)201–210, DOI: 10.1016/j.jcis.2009.05.022.

    51. Miscibility Behavior of Two-Component Monolayers at the Air–Water Interface: Perfluorocarboxylic Acids and DMPE, Hiroki Yokoyama, Hiromichi Nakahara, Takahiro Nakagawa, Satoshi Shimono, Kunihiko Sueishi, Osamu Shibata, Journal of Colloid and Interface Science 337(2009)191–200, DOI: 10.1016/j.jcis.2009.05.010.

    52. Pulmonary Surfactant Model Systems Catch the Specific Interaction of an Amphiphilic Peptide with Anionic Phospholipid, Hiromichi Nakahara, Sannamu Lee, Osamu Shibata, Biophysical Journal 96(2009)1415–1429, DOI: 10.1016/j.bpj.2008.11.022.

    53. Hysteresis Behavior of Amphiphilic Model Peptide in Lung Lipid Monolayers at the Air–Water Interface by an IRRAS Measurement, Hiromichi Nakahara, Anna Dudek, Yoshihiro Nakamura, Sannamu Lee, Chien-Hsiang Chang, Osamu Shibata, Colloids and Surfaces B: Biointerfaces 68(2009)61–67, DOI: 10.1016/j.colsurfb.2008.09.013.

    54. Development of Low Cost Pulmonary Surfactants Composed of a Mixture of Lipids or Lipids–Peptides Using Higher Aliphatic Alcohol or Soy Lecithin, Ko Yukitake, Yoshihiro Nakamura, Masato Kawahara, Hiromichi Nakahara, Osamu Shibata, Sannamu Lee, Colloids and Surfaces B: Biointerfaces 66(2008) 281–286, DOI: 10.1016/j.colsurfb.2008.07.007.

  • （競争的資金獲得状況）

    1. 令和5-7年度　　基盤研究C (課題番号：23K06076)、独立行政法人日本学術振興会、「フッ素ハイブリッド型人工調製肺サーファクタントの機能性及び界面透過機序の解明」、(360万円) 代表

    2. 令和元-4年度　　基盤研究C (課題番号：19K07036)、独立行政法人日本学術振興会、「人工調製肺サーファクタントの機能性フッ素ハイブリッド化への展開」、代表

    3. 平成28-30年度　　基盤研究C (課題番号：16K08216)、独立行政法人日本学術振興会、「革新的人工調製肺サーファクタントの開発と適用拡大への試み」、代表

    4. 平成25-26年度　　若手研究 B (課題番号：25790020)、独立行政法人日本学術振興会、「ハイブリッド型肺サーファクタントを応用した革新的ナノメディスンの創製」、代表

    5. 平成24年度　　財団法人油脂工業会館研究助成金、財団法人油脂工業会館、「人工調製肺サーファクタントへ添加を目的とする新規高機能性部分フッ素化合物の合成・基盤及び応用」、代表

    6. 平成22年度　　薬学系研究奨励、財団法人武田科学振興財団、「新規機能性海洋天然物を配合した次世代型人工調製肺サーファクタントへの応用展開」、代表

    7. 平成22年度　　海外渡航費補助制度、倉田記念日立科学技術財団、「Salt Concentration Effect on Surfactant Adsorption of Soluble Surfactants at the Air-Solution Interface」、代表

    8. 平成22-24年度　　若手研究 B (課題番号：22710106)、独立行政法人日本学術振興会、「新規ナノメディスンとしてのフッ素導入人工調製肺サーファクタントの開発と応用展開」、代表

    9. 平成21年度　　倉田奨励金、倉田記念日立科学技術財団、「界面近傍に於けるバイレイヤーアセンブルの形成過程とそのイメージング」、代表

    10. 平成20-21年度　　若手研究（スタートアップ）(課題番号：20810041)、独立行政法人日本学術振興会、「新規人工調製肺サーファクタントのインテリジェント・ナノ医薬としての試み」、代表

    11. 平成20年度    第20回加藤記念国際交流（海外派遣）助成金、「Role of phosphatidylglycerol in pulmonary surfactant preparations with an amphiphilic peptide at the air-water interface」、代表

    12. 平成18-19年度　　特別研究員奨励費 (課題番号：18.9587)、独立行政法人日本学術振興会、「新規人工調整肺サーファクタントの開発及びフッ素・ハイブリッド型への新たな展開」、代表

    13. 平成17年度　　学生の国際会議派遣に対する助成金、財団法人九州大学後援会、「Langmuir Monolayer Properties of a New Amphiphilic a-helical Peptide with Synthetic Lipids」、代表

    14. 平成16年度　　学生の独創的研究計画に対する助成金、財団法人九州大学後援会、「新規ペプチドを用いた人工肺サーファクタントの創製」、代表

  • （受賞）

    1. 平成27年4月27日　　日本油化学会進歩賞 (公益社団法人日本油化学会) 受賞

    2. 平成26年9月10日  17th Journal of Oleo Science Editors’Award (公益社団法人日本油化学会)　受賞

    3. 平成26年9月10日  5th Journal of Oleo Science Award for Best Author (公益社団法人日本油化学会)　受賞

    4. 平成24年3月23日  長崎県科学技術奨励賞 (長崎県)　受賞

    5. 平成23年10月25日  日本薬学会九州支部学術奨励賞 (日本薬学会)　受賞

    6. 平成19年9月7日　　日本油化学会ヤングフェロー賞 (日本油化学会) 受賞

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