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センター長 白谷 智宣

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スタッフ 主な担当科目 オフィスアワー
教授 柴山 周乃(医学博士) 臨床漢方治療学
薬学英語
ビジネスマナー論
水曜日 13:00~17:00
不在の場合はメールにて対応
教授 松本 欣三  (薬学博士) 漢方薬理学 水曜日 14:00~17:00
不在の場合はメールにて対応
教授 村山(田鶴谷) 惠子 (薬学博士) 製剤学Ⅰ
薬剤系実習
火曜日 15:00~17:00
不在時はメールで対応
教授 白谷 智宣 (博士(薬学)) 有機化学Ⅰ・Ⅱ
有機化学演習
化学系実習
月曜日・金曜日 15:00~17:00
不在の場合はメールにて対応
教授 窪 和広    
准教授 清水 典史 (博士(医学)) 機能形態学Ⅰ・Ⅱ
基礎生物学
薬理学実習
月曜日・木曜日 13:00~17:00
不在の場合はメールにて対応
准教授 高橋 義人 基礎化学Ⅰ・Ⅱ 月曜日・金曜日 15:00~17:00
不在の場合はメールにて対応 
講師 古賀 和隆 (博士(薬学)) 無機化学
有機化学演習
化学系実習
火曜日 14:00~17:00
不在の場合はメールにて対応
講師 跡部 秀之 基礎生物学 月曜日 15:00~17:00
不在の場合はメールにて対応
講師 鈴木 航介 (博士(数理科学)) 基礎数学Ⅰ・Ⅱ
情報処理演習Ⅰ・Ⅱ
薬学データサイエンス数学Ⅰ・Ⅱ
火曜日・金曜日 13:00~14:00
不在の場合はメールにて対応
助手 松延 千春 (修士(健康薬科学)) 薬剤学実習
事前学習
火曜日・木曜日 13:00~17:00
在室中で対応可能な場合は随時対応
助手 椿 友梨 (修士) 物理系実習 火曜日・木曜日 13:00~17:00
在室中で対応可能な場合は随時対応

 

教育・研究内容

柴 山

  • 中医学と日本漢方の養生法-予防医学の研究

松 本

  • 認知障害と発達障害の発症機構および漢方薬・天然薬物を用いた治療法の開発

白 谷

  • 薬学教育における学習成果の可視化手法の開発
  • 大環状芳香族化合物を用いた光機能材料の開発

清 水

  • 教育手法の有効性に関する研究
  • うつ病に関する研究

古 賀

  • 機能性シクロデキストリン誘導体および機能性環状化合物に関する研究

鈴 木

  • 準モンテカルロ法による高次元数値積分

松 延

  • 薬学教育に対するデータ解析

椿

  • 物理教育
  • 薬学教育に対するデータ解析
代表論文
  1. J. Dick, T. Goda, K. Suzuki: “Component-by-component construction of randomized rank-1 lattice rules achieving almost the optimal randomized error rate”, Mathematics of Computation 91, 2771–2801, (2022).
  2. Effects of chronic glucocorticoid receptor stimulation on circadian locomotor activity and serotonergic neurotransmission in the basolateral amygdala of rats. N. Shimizu, C. Hara., Biological and Pharmaceutical Bulletin, 43, 1279-1282, (2020).
  3. Understanding a student’s academic ability to pass the national examination for pharmacists with the pass/fail prediction model. N. Shimizu, H. Inoue, C. Matsunobu. Y. Tsubaki, T. Shiratani, Japanese Journal of Pharmaceutical Education., 3, (2019).
  4. Risk evasion and the economic impact of pharmaceutical intervention by community pharmacists. H. Koguchi, N. Sugimoto, T. Mitsuyasu, C. Matsunobu, T. Shiratani, T. Ikeuchi, S. Kaneshige, K. Ogata, H. Kamimura, Japanese pharmacology and therapeutics, 47,375-382(2019).
  5. 食品による生薬製剤のマスキング効果 城戸克己, 廣瀬恵美, 片岡裕美, 増田寿伸, 田鶴谷(村山)惠子 日本食品化学学会誌, 26(1), 68 -76 (2019)
  6. Matsumoto K, Fujiwara H, Araki R, Yabe T. Post-weaning social isolation of mice: a putative animal model of developmental disorders [Review]. J. Pharmacol. Sci. 141, 111-118, 2019.
  7. Tantipongpiradet A, Monthakantirat O, Vipatpakpaiboon O, Khampukdee C, Umehara K, Noguchi H, Fujiwara H, Matsumoto K, Sekeroglu N, Kijjoa A, Chulikhit Y. Effects of puerarin on the ovariectomy-induced depressive-like behavior in ICR mice and its possible mechanism of action. Molecules 24(24), 4568, 2019.
  8. Ueoka I, Pham HNT, Matsumoto K, Yamaguchi M. Autism spectrum disorder: modeling with Drosophila, rodents and C. elegans [Review]. International Journal of Molecular Sciences 20, 4071, 2019.
  9. Pham HTN, Phan SV, Tran HN, Phi XT, Le XT, Nguyen KM, Fujiwara H, Yoneyama M, Ogita K, Yamaguchi T, Matsumoto K. Bacopa monnieri (L.) Wettst. ameliorates cognitive deficits caused in a trimethyltin-induced neurotoxicity model mice. Biol Pharm Bull. 42, 1384–1393, 2019.
  10. Guo Q-Y, Ebihara K, Fujiwara H, Toume H, Awale S, Araki R, Yabe T, Dong E, Matsumoto K. Kami-shoyo-san ameliorates sociability deficits in ovariectomized mice, a putative female model of autism spectrum disorder, via facilitating dopamine D1 and GABAA receptor functions. J. Ethnopharmacol. 236, 231–239, 2019.
  11. Fujiwara H, Yoshida J, Dibwe DF, Awale S, Hoshino H, Kohama H, Arai H, Kudo Y, Matsumoto K. Orengedokuto and san’oshashinto improve memory deficits by inhibiting age-dependent GSK-3β activation and subsequent CRMP2 phosphorylation in senescence-accelerated prone 8 mice. J Tradit Complement Med. 9(4), 328-335, 2019.
  12. Guo Q-Y, Ebihara K, Fujiwara H, Toume H, Dibwe DF, Awale S, Araki R, Yabe T, Matsumoto K. Kami-shoyo-san ameliorates ASD-like behaviors by inhibiting allopregnanolone biosynthesis in the brain via dopaminergic and, in part, GABAergic mechanisms. PLOS One14(1), e0211266, 2019.
  13. D. Gunawan, M. N. Tran, K. Suzuki, J. Dick, R. Kohn: “Computationally effcient Bayesian estimation of high-dimensional Archimedean copulas with discrete and mixed margins”, Statistics and Computing 29(5) 933–946, (2019).
  14. K. Suzuki, T. Yoshiki: “Enumeration of the Chebyshev-Frolov lattice points in axis parallel boxes”, Hiroshima Mathematical Journal 49, 139–159, (2019).
  15. R. Hofer, K. Suzuki: “A complete classifcation of digital (0, m, 3)-nets and digital (0, 2)-sequences in base 2”, Uniform Distribution Theory 14(1), 43–51, (2019).
  16. T. Goda, K. Suzuki, T. Yoshiki: “Lattice rules in non-periodic subspaces of Sobolev spaces”, Numerische Mathematik 141(2), 399–427, (2019).
  17. 水質がウズ煎液中のアコニチン型ジエステルアルカロイド量に及ぼす影響.笛木司、別府正志、牧野利明、柴山周乃他.日本東洋医学雑誌.69(4):336-345、2018
  18. Establishment of pass/fail prediction model based on Support Vector Machine. N. Shimizu, H. Inoue, C. Matsunobu, E. Kohro, Y. Tsubaki, T. Shiratani, Japanese Journal of Pharmaceutical Education., 2, 141-147, (2018).
  19. 海洋性ピコプランクトンによるビタミンの産生と相互利用 田鶴谷(村山)惠子, 廣村信 ビタミン, 92(3), 132-135 (2018)
  20. Fujiwara H., Tsushima R., Okada R., Awale S., Araki R., Yabe T., Matsumoto K. Sansoninto, a traditional herbal medicine, ameliorates behavioral abnormalities and down-regulation of early growth response-1 expression in mice exposed to social isolation stress. J Tradit Complement Med. 8, 81-88, 2018.
  21. Araki R, Tohme K, Fujiwara H, Matsumoto K, Yabe T. Polygalae Radix extract ameliorates behavioral and neuromorphological abnormalities in mice treated chronically with corticosterone. Traditional & Kampo Medicine 5, 89-97, 2018.
  22. Hiraki Y, Araki R, Fujiwara H, Ago Y, Tanaka T, Toume K, Matsumoto K, Yabe T. Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice. J. Pharmacol. Sci. 139(2), 72-76, 2018.
  23. Kimura K, Matsumoto K, Ohtake H, Oka J-I, Fujiwara H. Endogenous acetylcholine regulates the expression levels of neuronal and astrocytic vascular endothelial growth factor (VEGF) via different acetylcholine receptor mechanisms. Neurochem Int. 118, 42-51, (2018).
  24. H. Kajiura, M. Matsumoto, K. Suzuki: “Characterization of matrices B such that (I,B,B2) generates a digital net with t-value zero”, Finite Fields and Their Applications 52, 289–300, (2018).
  25. J. Dick, F. Pillichshammer, K. Suzuki, M. Ullrich, T. Yoshiki: “Digital net properties of a polynomial analogue of Frolov’s construction”, Finite Fields and Their Applications 51, 325–350, (2018).
  26. T. Goda, K. Suzuki, T. Yoshiki: “Optimal Order Quadrature Error Bounds for Infinite Dimensional Higher-Order Digital Sequences”, Foundations of Computational Mathematics 18(2), 433–458, (2018).
  27. J. Dick, F. Pillichshammer, K. Suzuki, M. Ullrich, T. Yoshiki: “Lattice-based integration algorithms: Kronecker sequences and rank-1 lattices”, Annali di Matematica Pura ed Applicata (1923-) 197(1), 109–126, (2018).
  28. PM2.5中の水溶性成分がマスト細胞株の脱顆粒に及ぼす影響 片岡裕美、中村智美、田鶴谷(村山)惠子、山下沢、西川淳一 大気環境学会誌、52(1)、12-18 (2017).
  29. 古細菌のチアミン生合成経路の生化学的研究 林麻利亜、田鶴谷(村山)惠子、野坂和人 ビタミン(Vitamins (Japan),91(38-47), (2017)
  30. Sasaki-Hamada S, Suzuki A, Ueda Y, Matsumoto K, Oka JI. Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice. J. Pharmacol. Sci. 133: 110-113, 2017.
  31. Yokozawa T, Park CH, Matsumoto K. Scientific evidence for therapeutic effects of Chinese prescription Kangen-karyu from pre-clinical animal experiments [Review]. Drug Discov. Ther. 11(1), 6-14, 2017.
  32. Fujiwara H, Yaoyu H, Ebihara K, Awale S, Araki R, Yabe T, Matsumoto K. Daily administration of yokukansan and keishito prevents social isolation-induced behavioral abnormalities and down-regulation of phosphorylation of neuroplasticity-related signaling molecules in mice, BMC Complement Altern Med. 17(1), 195, 2017.
  33. Sasaki-Hamada S, Suzuki A, Sanai E, Matsumoto K, Oka J-I. Neuroprotection by chotosan, a Kampo formula, against glutamate excitotoxicity involves the inhibition of GluN2B-, but not GluN2A-containing NMDA receptor activation in primary cultured cortical neurons. J. Pharmacol. Sci. 135, 134-137, 2017.
  34. Awale S, Tawila AM, Dya Fita Dibwe, Ueda J-Y, Sun S, Athikomkulchai S, Balachandran C, Saiki I, Matsumoto K, Esumi H. Highly oxygenated antiausterity agents from the leaves of Uvaria dac. Bioorg Med Chem Lett. 27(9), 1967-1971, 2017.
  35. Dibwe DF, Sun S, Ueda JY, Balachandran C, Matsumoto K, Awale S. Discovery of potential antiausterity agents from the Japanese cypress Chamaecyparis obtuse. Bioorg Med Chem Lett. 27(21), 4898-4903, 2017.
  36. Ebihara K, Fujiwara H, Awale S, Fita Dibwe D, Araki R, Yabe T, Matsumoto K. Decrease in endogenous brain allopregnanolone induces autism spectrum disorder (ASD)-like behavior in mice: a novel animal model of ASD. Behav. Brain Res. 334, 6-15, 2017.
  37. K. Suzuki: “Super-polynomial convergence and tractability of multivariate integration for infnitely diferentiable functions”, Journal of Complexity 39, 51–68, (2017).
  38. J. Dick, T. Goda, K. Suzuki/u>, T. Yoshiki: “Construction of interlaced polynomial lattice rules for infnitely diferentiable functions”, Numerische Mathematik 137(2), 257–288, (2017).
  39. T. Goda, K. Suzuki, T. Yoshiki: “Optimal order quasi-Monte Carlo integration in weighted Sobolev spaces of arbitrary smoothness”, IMA Journal of Numerical Analysis 37(1), 505–518, (2017).
  40. Kijima Y, Hayashi M, Yamada K., Tazuya-Murayama K. The biosynthesis of the pyrimidine moiety of thiamin in Halobacterium salinarum J Nutr. Sci. Vitaminol., 62(2),130-133, 2016
  41. T. Goda, K. Suzuki, T. Yoshiki: “Quasi-Monte Carlo integration for twice differentiable functions over a triangle”, Journal of Mathematical Analysis and Applications 454(1), 361–384, (2017).
  42. 张伯礼教授临床用对(队)药经验谈.郑文科、柴山周乃、江丰.天津中医药、(8):449-452. 2016
  43. Araki R, Nishida S, Hiraki Y, Li F, Matsumoto K, Yabe T. Kamikihito Ameliorates Lipopolysaccharide-Induced Sickness Behavior via Attenuating Neural Activation, but Not Inflammation, in the Hypothalamic Paraventricular Nucleus and Central Nucleus of the Amygdala in Mice. Biol Pharm Bull. 39(2), 289-94, 2016.
  44. Nguyen HX, Nguyen NT, Dang PH, Thi PH, Nguyen MTT, Can MV, Dibwe D-F, Uedad J-Y, Matsumoto K, Awale S. A New Cassane-type Diterpene from the Seed of Caesalpinia sappan. Natural Product Comm. 11, 723-724, 2016.
  45. Araki R, Hiraki Y, Nishida S, Kuramoto N, Matsumoto K, Yabe T. Epigenetic regulation of dorsal raphe GABAB1a associated with isolation-induced abnormal behaviors in mice. Neuropharmacology 101, 1-12, 2016.
  46. Matsumoto K, Fujiwara H. Memory/Learning, Dementia and Kampo (in: Herbal Medicines New Horizons, Ed. Akio Inui), Methods in Pharmacology and Toxicology (Series title) (264pages, DOI: 10.1007/978-1-4939-4002-8), 2016, Sep. 22 Humana Press
  47. T. Goda, K. Suzuki, T. Yoshiki: “An explicit construction of optimal order quasi-Monte Carlo rules for smooth integrands”, SIAM Journal on Numerical Analysis 54(4), 264–283, (2016).
  48. T. Goda, R. Ohori, K. Suzuki, T. Yoshiki: “The Mean Square Quasi-Monte Carlo Error for Digitally Shifted Digital Nets”, In: R. Cools and D. Nuyens (eds.), Monte Carlo and Quasi-Monte Carlo Methods, Springer Proceedings in Mathematics and Statistics 163, 331–350, (2016).
  49. K. Suzuki, T. Yoshiki: “Formulas for the Walsh coeffcients of smooth functions and their application to bounds on the Walsh coeffcients”, Journal of Approximation Theory 205, 1–24, (2016).
  50. T. Goda, K. Suzuki, T. Yoshiki: “Digital nets with infnite digit expansion and construction of folded digital nets for quasi-Monte Carlo integration”, Journal of Complexity 33, 30–54, 2016.
  51. The biosynthesis of the thiazole moiety of thiamin in the archaeon, Halobacterium salinarum. Hayashi M, Kijima Y, Tazuya-Murayama K, Yamada K. J. Nutr. Sci. Vitaminol., 61(3), 270-274, 2015.
  52. Effect of adenosine system in the action of oseltamivir on behavior in mice.H. Uchiyama, M. Hiromura, T. Shiratani, H. Kuroki, S. Honda, K. Kosako, S. Soeda, K. Inoue, A. Toda, Neuroscience Letters 599(2015)7-11.
  53. K. Suzuki: “WAFOM on abelian groups for quasi-Monte Carlo point sets”, HiroshimaMathematical Journal 45(3), 341–364, (2015).
  54. T. Goda, K. Suzuki, T. Yoshiki: “The b-adic tent transformation for quasi-Monte Carlointegration using digital nets”, Journal of Approximation Theory 194, 62–86, (2015).
  55. Splenectomy modifies hyperactive states of the dopaminergic system induced by morphine in C57BL/6J-bg(J)/bg(J) (beige-J) mice. Funada M, Maeda J, Tsuda Y, Komiya S, Shimizu N, Kamei J, Suzuki T. Eur J Pharmacol. 2014. 742: 89-93.
  56. Enzymatic and structural characterization of an archaeal thiamin phosphate synthase. Biochim Biophys Acta.  Hayashi M, Kobayashi K, Esaki H, Konno H, Akaji K, Tazuya K, Yamada K, Nakabayashi T, Nosaka K. , 1844(4):803-9 (2014)
  57. 酵母のチアミン生合成経路に関するもう1つの自殺酵素Thi5: 田鶴谷(村山)惠子,林 麻利亜,山田 和子, ビタミン 88(3),161-164 (2014)
  58. K. Suzuki: “An explicit construction of point sets with large minimum Dick weight”, Journal of Complexity 30(3), 347–354, (2014).
  59. Involvement of dopamine D2 receptor signal transduction in the discriminative stimulus effects of the κ-opioid receptor agonist U-50,488H in rats. Mori T, Yoshizawa K, Ueno T, Nishiwaki M, Shimizu N, Shibasaki M, Narita M, Suzuki T. Behav. Pharmacol. 2013; 24: 275-281.
  60. Involvement of serotonin receptor mechanisms in the discriminative stimulus effects of ketamine in rats. Yoshizawa K, Mori T, Ueno T, Nishiwaki M, Shibasaki M, Shimizu N, Narita M, Suzuki T. J. Pharmacol. Sci.; 121: 237-241(2013).

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